Herpes Simplex Virus 2 expresses a novel form of ICP 34 . 5 , a 1 major viral neurovirulence factor , through regulated 2 alternative splicing
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چکیده
14 Corresponding author to whom reprint requests and inquiries should be addressed: 15 P.R. Krause, FDA/CBER, HFM-457, 29 Lincoln Drive, Bethesda, MD 20892-4555. 16 phone: 301-827-1914; fax: 301-496-1810; e-mail: [email protected] 17 Running title: Novel HSV-2 ICP34.5 protein expressed from unspliced transcript 18 19 20 21 Copyright © 2013, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.03500-12 JVI Accepts, published online ahead of print on 13 March 2013
منابع مشابه
Herpes simplex virus 2 expresses a novel form of ICP34.5, a major viral neurovirulence factor, through regulated alternative splicing.
Herpes simplex virus 1 (HSV-1) and HSV-2, two closely related neurotropic human herpesviruses, achieve neurotropism through ICP34.5, a major viral neurovirulence factor. In this report, in addition to the full-length 38-kDa protein (ICP34.5α), we identified a 28-kDa novel form of ICP34.5 (ICP34.5β) in HSV-2-infected cells. ICP34.5β is translated from unspliced ICP34.5 mRNA, with the retained in...
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تاریخ انتشار 2013